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Post by HangHang on Thu Dec 17, 2020 4:56 am

Alaska Health Worker Had a Serious Allergic Reaction After Pfizer's Vaccine ....

WASHINGTON — A health care worker in Alaska had a serious allergic reaction after getting Pfizer’s coronavirus vaccine Tuesday, symptoms that emerged within minutes and required an overnight hospital stay.

The middle-aged worker had no history of allergies but had an anaphylactic reaction that began 10 minutes after receiving the vaccine at Bartlett Regional Hospital in Juneau, Alaska, a hospital official said. She experienced a rash over her face and torso, shortness of breath and an elevated heart rate.

Dr. Lindy Jones, the hospital’s emergency department medical director, said the worker was first given a shot of epinephrine, a standard treatment for severe allergic reactions. Her symptoms subsided but then reemerged, and she was treated with steroids and an epinephrine drip.

When doctors tried to stop the drip, her symptoms reemerged yet again, so the woman was moved to the intensive care unit, observed throughout the night, then weaned off the drip early Wednesday morning, Jones said. He said the woman felt well, remained enthusiastic about the vaccine and was set to be discharged later Wednesday.

Although the Pfizer vaccine was shown to be safe and about 95% effective in a clinical trial involving 44,000 participants, the Alaska case will likely intensify concerns about possible side effects. Experts described the woman’s symptoms as potentially life-threatening and said that they may prompt calls for tighter guidelines to ensure that recipients are carefully monitored for adverse reactions.

Dr. Paul Offit, a vaccine expert and member of an outside advisory panel that recommended the Food and Drug Administration authorize the Pfizer vaccine for emergency use, said the appropriate precautions are already in place. For instance, he said, the requirement that recipients remain in place for 15 minutes after getting the vaccine helped ensure the woman was quickly treated.

“I don’t think this means we should pause" vaccine distribution, he said. “Not at all.” But he said researchers need to figure out “what component of the vaccine is causing this reaction.”

Dr. Jay Butler, a top infectious disease expert with the Centers for Disease Control, said the Alaska case showed the monitoring system works. The agency has recommended that the vaccine be administered in settings that have supplies, including oxygen and epinephrine, to manage anaphylactic reactions.

Millions of Americans are in line to be inoculated with the Pfizer vaccine by the end of the year. As of Wednesday night, it was unclear how many Americans have received it. Alex Azar, the health and human services secretary, said that his department will be releasing that data “several days or maybe a week into this.”

The Alaska woman’s reaction was believed to be similar to the anaphylactic reactions two health workers in Britain experienced after receiving the Pfizer-BioNTech vaccine last week. Like her, both recovered.

Those cases are expected to come up Thursday, when FDA scientists are scheduled to meet with the agency’s outside panel of experts to decide whether to recommend that regulators approve Moderna’s COVID-19 vaccine for emergency use.

Although Moderna and Pfizer-BioNTech vaccines are both based on the same type of technology and are similar in their ingredients, it is not clear whether an allergic reaction to one would occur with the other. Both consist of genetic material called mRNA encased in a bubble of oily molecules called lipids, although they use different combinations of lipids.

Offit said in both vaccines, the bubbles are coated with a stabilizing molecule called polyethylene glycol that he considers a “leading contender” for triggering an allergic reaction. He stressed that more investigation is needed.

Pfizer’s trial did not find any serious adverse events caused by the vaccine, although many participants did experience aches, fevers and other side effects. The Alaska woman’s reaction was assumed to be related to the vaccine because it occurred so quickly after the shot.

A Pfizer spokesperson, Jerica Pitts, said that the company does not yet have all the details of the case but is working with local health authorities. The vaccine comes with information warning that medical treatment should be available in case of a rare anaphylactic event, she said. “We will closely monitor all reports suggestive of serious allergic reactions following vaccination and update labeling language if needed,” Pitts said.

After the workers in Britain fell ill, authorities there initially warned against giving the vaccines to anyone with a history of severe allergic reactions. They later clarified their concerns, changing the wording from “severe allergic reactions” to specify that the vaccine should not be given to anyone who has ever had an anaphylactic reaction to a food, medicine or vaccine. That type of reaction to a vaccine is “very rare,” they said.

Pfizer officials have said the two British people who had the reaction had a history of severe allergies. One, a 49-year-old woman, had a history of egg allergies. The other, a 40-year-old woman, had a history of allergies to several different medications. Both carried EpiPen-like devices to inject themselves with epinephrine in case of such a reaction.

Pfizer has said that its vaccine does not contain egg ingredients.

The British update also said that a third patient had a “possible allergic reaction” but did not describe it.

In the United States, federal regulators issued a broad authorization for the vaccine Friday to adults 16 years and older. Health care providers were warned not to give the vaccine to anyone with a “known history of a severe allergic reaction” to any component of the vaccine, which they said was a standard warning for vaccines.

But because of the British cases, FDA officials have said they would require Pfizer to increase its monitoring for anaphylaxis and submit data on it once the vaccine comes into use. Pfizer also said that the vaccine is recommended to be administered in settings that have access to equipment to manage anaphylaxis. Last weekend, the Centers for Disease Control and Prevention said that people with serious allergies can be safely vaccinated with close monitoring for 30 minutes after receiving the shot.


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Post by Rice on Thu Dec 17, 2020 10:49 am

nói tới vaccine thì phải có side effects thôi chị, that's why mình cần phải có strategy chị, ví dụ strategy của nhà Gạo hiện tại là vậy:
1. covid vaccine nhà Gạo sẽ đi tới văn phòng bác sỹ chứ không đi tới CVS or Walgreen để chích . Thường chích thuốc mới, phảI ngồi ở chổ chích khoảng 15' đợi xem có bị phản ứng không . Gạo sẽ ngồi phòng đợi 1 hour mới về
2. ox Gạo sẽ đi chích trước, Gạo sẽ đi chích sau him 6 tuần vì Gạo muốn đợi him chích mũi thứ 2, 2 tuần sau Gạo mới đi
3. khi có vaccine cho mấy đứa nhỏ Gạo cũng cho đứa lớn chích trước vì nó lớn tuổi hơn, và nó không bị allergy gì cả, 2 tháng sau mới cho thằng em đi . Thằng em Gạo phải viết ra list bây giờ ~ thứ nó bị allergy như là lông mèo, pollen, ...


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Post by HangHang on Thu Dec 17, 2020 1:21 pm

Good morning bé Rice ,

Ở Alaska có người bị dị ứng với vaccines .... Cũng may là nhân viên cũa nhà thương ... Nên kịp thời chữa trị .

Thời buổi bây giờ nhà thương out of bed .... Xe cứu thương còn xếp hàng ngoài bịnh viện .... Nhỡ có bịnh khó mà chen lọt vô nhà thương .

Bởi thế lúc nào chị cũng khuyên khoan chích thuốc Covid ... Chị đã nói trước khi có vaccines khg nên chích ....
Mình đã chịu đựng hơn qua 9 thì tại sao khg đợi thêm dài tháng nữa ?

Lúc nhỏ chị bị bịnh sốt xuất huyết , nhà chị 2 đứa bị bịnh chị sống , em chị chết .... Thập tử, nhất sinh .... Nên chị có kinh nghiệm .

Ba chị làm bác sĩ phòng thí nghiệm .... Vì con bịnh cũa chị , nên ba chị lập phòng thí nghiệm tại nhà đễ nghiên cứu con bịnh . Tìm khg ra cuối cùng ba chị cho thuốc double dose thuốc chị mới sống khoẽ mạnh.

Ở Mỹ các bác si khg dám cho double dose như ba chị did cho chị .



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